左华老师简介
左华,女,硕士生导师,2008年博士毕业于昌原大学(韩国),同年以特聘副教授身份进入西南大学药学院工作,2010年被评为副教授,2018年晋升为教授。
主要研究领域:核酸(DNA和RNA)自组装及在药学中的应用;药物及中间体合成;荧光有机小分子探针的合成及应用。
教学内容:承担研究生和本科的《波谱解析》、《有机化学》、《药物合成反应》、《药学英语》、《Organic Chemistry》(全英语教学)等专业课程。
主持/参与课题:主持国家自然科学基金1项、教育部基金1项、重庆市自然科学基金1项,四川省科技厅科技支撑项目子课题1项,中央高校科研业务项目3项,参与国家及省部级科研项目3项。
代表论文:
(1)Zuo, H.; Mao, C*. Drugging the undruggable molecules by a DNA nanorobot. Sci. China Chem. 2018, 61 (7) , 763.
(2)Zuo, H.*; Wu, S.; Li, M.; Li, Y.; Jiang, W.; Mao, C*. A case study of the likes and dislikes of DNA and RNA in self-assembly. Angew. Chem. Int. Edit. 2015, 54, 15118. (Selected as inside cover and hot paper)
(3)Li, M.; Zuo, H.*; Yu, J. W.; Zhao, X. F.; Mao, C*. One DNA strand homo- polymerizes into defined nanostructures. Nanoscale 2017, 9 (30), 10601.
(4)Xia, S.; Xiao, S.-Y.; Hong, Q.-Q.; Zou, J.-R.; Yang, S.; Zhang, M.-X.; Zuo, H*. A novel sensitive fluorescent turn-on probe for rapid detection of Al3+ and bioimaging. RSC Adv.2015, 5, 5244.
(5)Tan, J.-L.; Zhang, M.-X.; Zhang, F.; Yang, T.-T.; Liu, Y.; Li, Z.-B.; Zuo, H*. A novel ‘‘off–on’’ colorimetric and fluorescent rhodamine-based pH chemosensor for extreme acidity. Spectrochim Acta A Mol Biomol Spectrosc. 2015, 140, 489.
(6)Xia, S.; Liu, J.-Q.; Wang, X.-H.; Tian, Y.; Wang, Y.; Wang , J.-H.; Fang, L.; Zuo, H. * Smiles rearrangement for the synthesis of 4,7-disubstituted-2H-benzo[b][1,4]-oxazin-3(4H)-ones and their in vitro evaluation as platelet aggregation inhibitors. Bioorg. Med. Chem. Lett, 2014, 24 (6), 147.
(7)Xia, S.; Wang, L.-Y.; Zuo, H. *; Li, Z.-B.; Smiles rearrangement in synthetic chemistry. Cur. Org. Syn. 2013, 10 (6), 935.
(8)Tian, X.; Wang, L.-Y.; Xia, S.; Li, Z.-B.; Liu, X.-H.; Yuan, Y.; Fang, L.; Zuo, H.*, Synthesis of 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as platelet aggregation inhibitors. Bioorg. Med. Chem. Lett. 2012, 22 (1), 204.
(9)Yang, H.; Li, Z.-B.; Shin, D.-S.; Wang, L.-Y.; Zhou, J.-Z.; Qiao, H.-B.; Tian, X.; Ma, X.-Y.; Zuo, H.* A facile C-N bond formation: one-pot reaction of phenols and amines viaSmiles rearrangement. SYNLETT 2010, 3, 483.
(10)Zuo, H.; Li, Z.-B.; Ren, F.-K.; J. R. Falck; Meng, L.; Ahn, C.; Shin, D.-S. Microwave- assisted one-pot synthesis of benzo[b][1,4]thiazin-3(4H)-ones via Smiles rearrangement. Tetrahedron 2008, 64, 9669.
(11)Zuo, H.; Meng, L.; Ghate, M.; Hwang, K.-H.; Cho, Y.-K.; Chandrasekhar, S.; Reddy, C. R.; Shin, D.-S. Microwave-assisted one-pot synthesis of benzo[b] [1,4]oxazin-3(4H)-ones via Smiles rearrangement. Tetrahedron Lett. 2008, 49, 3827.
授权的专利:
1.左华,杨浩,李逐波 等,N-芳烷基苯胺类化合物的合成方法,2012年12月授权,中国发明专利,ZL 200910104093.1.
2.李逐波,任方奎,左华 等,低刺激性大蒜素衍生物及其合成方法和应用,2011 年7 月授权,中国发明专利,ZL 2008 10070362.2
3.李逐波,廖丹丹,赵晨光,左华 等,苦参碱磺酸钠及其制备方法,2011 年7 月授权,中国发明专利,ZL 200910104092.7